Ram and Asha were a married couple with four children — one had sickle cell anaemia; others showed no symptoms. Ram and Asha showed no symptoms. The trait is not sex-linked. (a) Is the disease caused by a dominant or recessive trait? Why? (b) If the affected child married a person without a mutation in the sickle cell gene, what percentage of their children would have sickle cell anaemia? Show the cross. OR (b) Identify the genetic composition of the sickle cell trait in Asha and Ram and use that to predict the genetic composition in the other four children who did not show symptoms.
- [1 mark] (a) The disease is caused by a recessive trait — both parents are unaffected yet a child is affected, so the trait appears only when both recessive alleles come together.
- [1 mark] (a) Therefore both Ram and Asha must be heterozygous carriers (Ss); the trait skips generations, which is characteristic of recessive inheritance.
- [1 mark] (b) Affected child (ss) × person with no mutation (SS): the cross ss × SS gives all offspring Ss ⟹ 0% affected, 100% carriers.
- [1 mark] (b OR) Ram (Ss) × Asha (Ss) → 1 SS : 2 Ss : 1 ss; the three unaffected children are either SS or Ss, while the affected child is ss.
